WASHINGTON — Secretary of State John Kerry warned Prime Minister Benjamin Netanyahu of Israel on Wednesday that the Israeli government was undermining any hope of a two-state solution to its decades-long conflict with the Palestinians, and said that the American vote in the United Nations last week was driven by an effort to save Israel from “the most extreme elements” in its own government.

With only 23 days left as secretary of state, Mr. Kerry, the former presidential candidate who made the search for peace in the Middle East one of the driving missions of his four years as secretary, spoke with clear frustration about Mr. Netanyahu’s continued support of settlements “strategically placed in locations that make two states impossible.” But he spoke knowing that the incoming administration of President-elect Donald J. Trump may well abandon the key principles that the United States has used for decades of Middle East negotiations.

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