Iran and the United States are currently engaged in a second round of high-level nuclear negotiations, this time in Rome. These indirect talks follow earlier discussions in Muscat, Oman, which were described as “constructive” by both sides. Because the US and Iran haven’t had formal diplomatic relations since 1979, they are not speaking directly. Instead, an Omani official is relaying messages between Iran’s Foreign Minister Abbas Araghchi and US Middle East envoy Steve Witkoff. The negotiations are taking place at Oman’s diplomatic office in Rome.

Iran’s main focus in these talks is securing the removal of US sanctions, particularly on its banking and oil sectors, which have severely impacted its economy. Tehran also wants guarantees that the US won’t back out of any future deal, as it did in 2018 under President Trump when the US exited the 2015 nuclear agreement. Iran continues to emphasize that its nuclear program is for peaceful purposes and insists on its right to enrich uranium for civilian use. However, Iranian officials have also warned against expecting a quick resolution.

The US, on the other hand, is pressing Iran to stop producing highly enriched uranium, fearing it could be used for nuclear weapons. While the US has hinted at possible military action if diplomacy fails, it has also signaled flexibility, at times appearing open to a tightly supervised civilian nuclear program in Iran. This shifting stance has created some uncertainty around the US’s final negotiating position.

These discussions are unfolding amid increased regional tensions, including the ongoing Israel-Hamas conflict and recent US airstrikes on Iranian-backed forces in Yemen. Israel is deeply skeptical of diplomacy with Iran and has suggested it might take action to prevent Iran from advancing its nuclear program.

The latest round of talks began on the morning of April 19, 2025. Before the session, Araghchi met with Italy’s Foreign Minister Antonio Tajani, while Witkoff consulted with Israeli officials in Paris. The talks are taking place under heightened pressure, especially after the International Atomic Energy Agency (IAEA) recently stated that Iran is nearing nuclear weapons capability.

Despite the tense backdrop, Iranian officials say a deal is achievable if the US avoids “maximalist” positions and instead takes a pragmatic approach. Iran wants verifiable relief from sanctions, and the US is looking for firm commitments on curbing uranium enrichment. The outcome could significantly affect both regional stability and broader efforts to prevent the spread of nuclear weapons.