Russians warplanes have conducted missions over Syria from an airbase in Iran — the first time a major power has done so since the Islamic Revolution there in 1979.

Tu-22M3 long-range bombers and Su-34 tactical bombers took off from Hamedan airbase in western Iran Tuesday, and hit targets belonging to ISIS and the Jabhat al-Nusra militant group in the Syrian provinces of Aleppo, Deir Ezzor and Idlib, Russia’s defense ministry said in a statement.

The raids “eliminated” five major arms depots, used to supply ISIS militants near the city of Aleppo, as well as three militant command points and training camps in the cities of Serakab, Al-Bab, Aleppo and Deir Ezzor.

A “significant number of militants” were also thought to be killed, the ministry said.